Biology:Aminoglycoside N3'-acetyltransferase
From HandWiki
| aminoglycoside N3'-acetyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.81 | ||||||||
| CAS number | 60120-42-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an aminoglycoside N3'-acetyltransferase (EC 2.3.1.81) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + a 2-deoxystreptamine antibiotic [math]\displaystyle{ \rightleftharpoons }[/math] CoA + N3'-acetyl-2-deoxystreptamine antibiotic
Thus, the two substrates of this enzyme are acetyl-CoA and 2-deoxystreptamine antibiotic, whereas its two products are CoA and N3'-acetyl-2-deoxystreptamine antibiotic.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase. Other names in common use include 3'-aminoglycoside acetyltransferase, and 3-N-aminoglycoside acetyltransferase.
References
- "Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin". Antimicrob. Agents Chemother. 14 (1): 69–72. 1978. doi:10.1128/aac.14.1.69. PMID 356726.
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