Biology:Beta-pyrazolylalanine synthase
| Beta-pyrazolylalanine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.51 | ||||||||
| CAS number | 37290-81-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Beta-pyrazolylalanine synthase (EC 2.5.1.51) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
It was first characterised from Leucaena leucocephala and transfers the 2-amino-2-carboxyethyl group from its substrate, the amino acid O-acetylserine, to pyrazole, giving β-pyrazolyl-L-alanine. Acetic acid (CH
3CO
2H) is a byproduct.[1][2] The enzyme is also found in Citrullus vulgaris (watermelon) and, unlike some other cysteine synthase enzymes which use O-acetylserine, in this species is specific for pyrazole.[3][4]
This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include beta-(1-pyrazolyl)alanine synthase, beta-pyrazolealanine synthase, beta-pyrazolylalanine synthase (acetylserine), O3-acetyl-L-serine acetate-lyase (adding pyrazole), BPA-synthase, pyrazolealanine synthase, pyrazolylalaninase, and 3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase.[5]
References
- ↑ "The enzymic synthesis of beta-substituted alanines". Phytochemistry 11 (1): 177–182. 1972. doi:10.1016/S0031-9422(00)89986-0. Bibcode: 1972PChem..11..177M.
- ↑ "Purification and characterization of L-mimosine synthase from Leucaena leucocephala". Phytochemistry 23 (9): 1905–1908. 1984. doi:10.1016/S0031-9422(00)84938-9. Bibcode: 1984PChem..23.1905M.
- ↑ "Purification and characterization of beta-(pyrazol-1-yl)-L-alanine synthase from Citrullus vulgaris". Phytochemistry 23 (5): 973–977. 1984. doi:10.1016/S0031-9422(00)82594-7. Bibcode: 1984PChem..23..973M.
- ↑ "Evidence for identity of beta-pyrazolealanine synthase with cysteine synthase in watermelon: formation of beta-pyrazole-alanine by cloned cysteine synthase in vitro and in vivo". Biochem. Biophys. Res. Commun. 197 (3): 1111–7. 1993. doi:10.1006/bbrc.1993.2592. PMID 8280125. Bibcode: 1993BBRC..197.1111N.
- ↑ Enzyme 2.5.1.51 at KEGG Pathway Database.
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