Biology:Chrysanthemyl diphosphate synthase
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Short description: Class of enzymes
| Chrysanthemyl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.67 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a chrysanthemyl diphosphate synthase (EC 2.5.1.67) is an enzyme involved in the biosynthesis of terpenoids. This enzyme is also known as CPPase. It catalyzes the chemical reaction shown below (color-coded to show how precursors link):
The substrate of CPPase is dimethylallyl diphosphate. The two products are diphosphate and chrysanthemyl diphosphate.
This enzyme is involved in the biosynthesis of pyrethrins, highly potent insecticides found in some flowers. The systematic name of this enzyme class is dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming).
References
- "Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4373–8. 2001. doi:10.1073/pnas.071543598. PMID 11287653. Bibcode: 2001PNAS...98.4373R.
- "Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway". J. Am. Chem. Soc. 125 (23): 6886–8. 2003. doi:10.1021/ja034520g. PMID 12783539.
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