Biology:Copalyl diphosphate synthase
From HandWiki
| copalyl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.5.1.12 | ||||||||
| CAS number | 157972-08-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a copalyl diphosphate synthase (EC 5.5.1.12) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] (+)-copalyl diphosphate
Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and one product, (+)-copalyl diphosphate.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is (+)-copalyl-diphosphate lyase (decyclizing). This enzyme participates in diterpenoid biosynthesis.
References
- RB; Flory, JE; Jetter, R; Ravn, MM; Lee, HJ; Coates, RM; Croteau, RB (2000). "Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme". Biochemistry 39 (50): 15592–602. doi:10.1021/bi001997l. PMID 11112547.
- "Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites". J. Am. Chem. Soc. 123 (37): 8974–8. 2001. doi:10.1021/ja010670k. PMID 11552804.
- "Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 580–4. 2002. doi:10.1073/pnas.022627099. PMID 11805316. Bibcode: 2002PNAS...99..580P.
- "Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates". J. Am. Chem. Soc. 124 (24): 6998–7006. 2002. doi:10.1021/ja017734b. PMID 12059223.
- "Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate". Biochemistry 41 (6): 1836–42. 2002. doi:10.1021/bi011879d. PMID 11827528.
 |  |
