Biology:FREM2
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 Generic protein structure example |
FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene.[1][2]
This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome.[2]
References
- ↑ "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A 101 (37): 13560–5. Sep 2004. doi:10.1073/pnas.0402760101. PMID 15345741. Bibcode: 2004PNAS..10113560S.
- ↑ 2.0 2.1 "Entrez Gene: FREM2 FRAS1 related extracellular matrix protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=341640.
Further reading
- "Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene.". Proc. Natl. Acad. Sci. U.S.A. 102 (33): 11746–50. 2005. doi:10.1073/pnas.0505404102. PMID 16087869. Bibcode: 2005PNAS..10211746T.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. 2004. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.". Nat. Genet. 37 (5): 520–5. 2005. doi:10.1038/ng1549. PMID 15838507.
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
- "Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11981–6. 2006. doi:10.1073/pnas.0601011103. PMID 16880404. Bibcode: 2006PNAS..10311981K.
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