Biology:Gentamicin 2'-N-acetyltransferase
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gentamicin 2'-N-acetyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.3.1.59 | ||||||||
CAS number | 50864-40-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a gentamicin 2'-N-acetyltransferase (EC 2.3.1.59) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + gentamicin C1a [math]\displaystyle{ \rightleftharpoons }[/math] CoA + N2'-acetylgentamicin C1a
Thus, the two substrates of this enzyme are acetyl-CoA and gentamicin C1a, whereas its two products are CoA and N2'-acetyl gentamicin C1a.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:gentamicin-C1a N2'-acetyltransferase. Other names in common use include gentamicin acetyltransferase II, gentamicin 2'-N-acetyltransferase, and acetyl-CoA:gentamicin-C1a N2'-acetyltransferase.
References
- "Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria". Proc. Natl. Acad. Sci. U.S.A. 70 (8): 2276–80. 1973. doi:10.1073/pnas.70.8.2276. PMID 4209515.
![]() | Original source: https://en.wikipedia.org/wiki/Gentamicin 2'-N-acetyltransferase.
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