Biology:Glutathione gamma-glutamylcysteinyltransferase

From HandWiki
glutathione gamma-glutamylcysteinyltransferase
Identifiers
EC number2.3.2.15
CAS number125390-02-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) is an enzyme that catalyzes the chemical reaction

glutathione + [Glu(-Cys)]n-Gly [math]\displaystyle{ \rightleftharpoons }[/math] Gly + [Glu(-Cys)]n+1-Gly

Thus, the two substrates of this enzyme are glutathione and [Glu(-Cys)]n-Gly, whereas its two products are Gly and [Glu(-Cys)]n+1-Gly.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2BTW and 2BU3.

References