Biology:Glycerophospholipid acyltransferase (CoA-dependent)
From HandWiki
| glycerophospholipid acyltransferase (CoA-dependent) | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.148 | ||||||||
| CAS number | 9054-54-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glycerophospholipid acyltransferase (CoA-dependent) (EC 2.3.1.148) is an enzyme that catalyzes the chemical reaction
- 1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine [math]\displaystyle{ \rightleftharpoons }[/math] 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine
Thus, the two substrates of this enzyme are 1-organyl-2-acyl-sn-glycero-3-phosphocholine and 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine, whereas its two products are 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine and 1-organyl-2-lyso-sn-glycero-3-phosphocholine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-gly cero-3-phosphoethanolamine acyltransferase (CoA-dependent).
References
- "Transfer of arachidonic acid between phospholipids in rat liver microsomes". Biochem. Biophys. Res. Commun. 91 (4): 1399–405. 1979. doi:10.1016/0006-291X(79)91222-1. PMID 526311.
- "Acylation of lysophospholipids by rabbit alveolar macrophages Specificities of CoA-dependent and CoA-independent reactions". J. Biol. Chem. 260 (13): 7889–95. 1985. PMID 4008481.
- "The role of transacylases in the metabolism of arachidonate and platelet activating factor". Prog. Lipid Res. 31 (1): 65–86. 1992. doi:10.1016/0163-7827(92)90016-C. PMID 1641397. https://zenodo.org/record/1258345.
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