Biology:Glycylpeptide N-tetradecanoyltransferase 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene. It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes.

Further reading

• "N-myristoyltransferase.". Mol. Cell. Biochem. 204 (1–2): 135–55. 2000. doi:10.1023/A:1007012622030. PMID 10718634. 
• "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. 2001. doi:10.1093/embo-reports/kve141. PMID 11463741. 
• "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". J. Cell Biol. 116 (2): 405–22. 1992. doi:10.1083/jcb.116.2.405. PMID 1530946. 
• "G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728–32. 1990. doi:10.1073/pnas.87.2.728. PMID 2153964. Bibcode: 1990PNAS...87..728M. 
• "Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly". AIDS Res. Hum. Retroviruses 6 (6): 721–30. 1990. doi:10.1089/aid.1990.6.721. PMID 2194551. https://zenodo.org/record/1235233. 
• "Myristoylation-dependent replication and assembly of human immunodeficiency virus 1". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 523–7. 1990. doi:10.1073/pnas.87.2.523. PMID 2405382. Bibcode: 1990PNAS...87..523B. 
• "Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal diethylacetal resulted in inhibition of virus production". Biochem. Biophys. Res. Commun. 165 (3): 1145–54. 1990. doi:10.1016/0006-291X(89)92722-8. PMID 2692561. 
• "Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein". Eur. J. Biochem. 182 (2): 323–6. 1989. doi:10.1111/j.1432-1033.1989.tb14833.x. PMID 2737204. 
• "Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5781–5. 1989. doi:10.1073/pnas.86.15.5781. PMID 2788277. Bibcode: 1989PNAS...86.5781G. 
• "Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein". Science 227 (4685): 427–9. 1985. doi:10.1126/science.3917576. PMID 3917576. Bibcode: 1985Sci...227..427S. 
• "Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase". J. Biol. Chem. 269 (16): 11691–4. 1994. doi:10.1016/S0021-9258(17)32626-1. PMID 7512951. 
• "Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". J. Virol. 68 (10): 6644–54. 1994. doi:10.1128/JVI.68.10.6644-6654.1994. PMID 7521919. 
• "Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12253–7. 1995. doi:10.1073/pnas.91.25.12253. PMID 7527558. 
• "Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids". J. Virol. 68 (4): 2556–69. 1994. doi:10.1128/JVI.68.4.2556-2569.1994. PMID 8139035. 
• "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. 1993. doi:10.1016/S0021-9258(17)46711-1. PMID 8360179. 
• "Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding". J. Biol. Chem. 271 (5): 2868–73. 1996. doi:10.1074/jbc.271.5.2868. PMID 8576268. 
• "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Differential membrane binding of the human immunodeficiency virus type 1 matrix protein". J. Virol. 70 (12): 8540–8. 1997. doi:10.1128/JVI.70.12.8540-8548.1996. PMID 8970978. 
• "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 

See also

• Myristoylation
• N-myristoyltransferase 2

External links

• Overview of all the structural information available in the PDB for UniProt: P30419 (Glycylpeptide N-tetradecanoyltransferase 1) at the PDBe-KB.