Biology:Lovastatin nonaketide synthase
From HandWiki
| lovastatin nonaketide synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.1.161 | ||||||||
| CAS number | 235426-97-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine [math]\displaystyle{ \rightleftharpoons }[/math] dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H+, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO2, NADP+, S-adenosyl-L-homocysteine, and H2O.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).
References
- "Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue". J. Am. Chem. Soc. 122 (46): 11519–11520. 2000. doi:10.1021/ja003216.
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