Biology:M7GpppN-mRNA hydrolase
From HandWiki
| M7GpppN-mRNA hydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.6.1.62 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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M7GpppN-mRNA hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- m7G5'ppp5'-mRNA + H2O [math]\displaystyle{ \rightleftharpoons }[/math] m7GDP + 5'-phospho-mRNA
Decapping of mRNA is essential in eukaryotic mRNA turnover.
References
- ↑ "Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development". The Plant Cell 18 (12): 3386–98. December 2006. doi:10.1105/tpc.106.047605. PMID 17158604.
- ↑ "hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA". Protein & Cell 2 (1): 64–73. January 2011. doi:10.1007/s13238-011-1009-2. PMID 21337011.
- ↑ "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". The EMBO Journal 21 (24): 6915–24. December 2002. doi:10.1093/emboj/cdf678. PMID 12486012.
- ↑ "Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression". Proceedings of the National Academy of Sciences of the United States of America 104 (7): 2139–44. February 2007. doi:10.1073/pnas.0611685104. PMID 17283339. Bibcode: 2007PNAS..104.2139P.
- ↑ "Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism". The Biochemical Journal 420 (1): 27–35. April 2009. doi:10.1042/BJ20082296. PMID 19210265.
- ↑ "Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses". Journal of Virology 81 (23): 12973–8. December 2007. doi:10.1128/JVI.01668-07. PMID 17881455.
- ↑ "Multiple mRNA decapping enzymes in mammalian cells". Molecular Cell 40 (3): 423–32. November 2010. doi:10.1016/j.molcel.2010.10.010. PMID 21070968.
External links
- M7GpppN-mRNA+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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