Biology:Marneral synthase
From HandWiki
Short description: Class of enzymes
| Marneral synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.4.99.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Marneral synthase (EC 5.4.99.53) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).[1] This enzyme catalyses the following chemical reaction
- (3S)-2,3-epoxy-2,3-dihydrosqualene marneral
Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of the Iridaceae, originally identified by Dr. Franz-Josef Marner[1]
This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.[2]
References
- ↑ 1.0 1.1 "An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob fragmentation". Angewandte Chemie 45 (8): 1285–8. February 2006. doi:10.1002/anie.200503420. PMID 16425307. Bibcode: 2006ACIE...45.1285X.
- ↑ "Formation of plant metabolic gene clusters within dynamic chromosomal regions". Proceedings of the National Academy of Sciences of the United States of America 108 (38): 16116–21. September 2011. doi:10.1073/pnas.1109273108. PMID 21876149. Bibcode: 2011PNAS..10816116F.
External links
- Marneral+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
