Biology:Non-specific polyamine oxidase
From HandWiki
Short description: Class of enzymes
| Non-specific polyamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.3.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- (1) spermine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] spermidine + 3-aminopropanal + H2O2
- (2) spermidine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] putrescine + 3-aminopropanal + H2O2
- (3) N1-acetylspermine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] spermidine + 3-acetamidopropanal + H2O2
- (4) N1-acetylspermidine + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] putrescine + 3-acetamidopropanal + H2O2
This enzyme is flavoprotein (FAD).
References
- ↑ "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". Plant Physiology 147 (4): 1845–57. August 2008. doi:10.1104/pp.108.123802. PMID 18583528.
- ↑ "Purification and characterization of polyamine oxidase from Ascaris suum". The Biochemical Journal 283 ( Pt 1): 75–80. April 1992. PMID 1567380.
- ↑ "Yeast Fms1 is a FAD-utilizing polyamine oxidase". Biochemical and Biophysical Research Communications 303 (3): 771–6. April 2003. doi:10.1016/s0006-291x(03)00416-9. PMID 12670477.
External links
- Non-specific+polyamine+oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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