Biology:Phosphoribosyl-ATP diphosphatase

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Short description: Class of enzymes
phosphoribosyl-ATP diphosphatase
1yxb.jpg
phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor
Identifiers
EC number3.6.1.31
CAS number69553-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-ATP + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-(5-phosphoribosyl)-AMP + diphosphate

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.

This enzyme participates in histidine metabolism. It employs one cofactor, H+.

Nomenclature

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.

References

  • "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". The Journal of Biological Chemistry 240: 3056–63. July 1965. PMID 14342333.