Biology:Phosphoribosyl-ATP diphosphatase
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Short description: Class of enzymes
phosphoribosyl-ATP diphosphatase | |||||||||
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phosphoribosyl-ATP pyrophosphatase tetramer, Streptomyces coelicolor | |||||||||
Identifiers | |||||||||
EC number | 3.6.1.31 | ||||||||
CAS number | 69553-55-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a phosphoribosyl-ATP diphosphatase (EC 3.6.1.31) is an enzyme that catalyzes the chemical reaction
- 1-(5-phosphoribosyl)-ATP + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 1-(5-phosphoribosyl)-AMP + diphosphate
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-ATP and H2O, whereas its two products are 1-(5-phosphoribosyl)-AMP and diphosphate.
This enzyme participates in histidine metabolism. It employs one cofactor, H+.
Nomenclature
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is 1-(5-phosphoribosyl)-ATP diphosphohydrolase. Other names in common use include phosphoribosyl-ATP pyrophosphatase, and phosphoribosyladenosine triphosphate pyrophosphatase.
References
- "Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis". The Journal of Biological Chemistry 240: 3056–63. July 1965. PMID 14342333.
Original source: https://en.wikipedia.org/wiki/Phosphoribosyl-ATP diphosphatase.
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