Biology:SH3KBP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
SH3 domain-containing kinase-binding protein 1 (synonyms - CIN85[1], in rodents - Ruk[2]) is an adaptor protein that in humans is encoded by the SH3KBP1 gene.[3][4]
Function
CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][5]
Interactions
SH3KBP1 has been shown to interact with B-cell linker,[6] Grb2,[7][8] SH3GLB2,[9][10] SH3GL3,[9] SH3GL2,[10] BCAR1,[6] Epidermal growth factor receptor,[10][11] CBLB,[11] Cbl gene,[6][8][9][10][11] SOS1,[6] CRK[6] and PAK2.[12]
References
- ↑ Database, GeneCards Human Gene. "SH3KBP1 Gene - GeneCards | SH3K1 Protein | SH3K1 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=SH3KBP1.
- ↑ "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal 19 (15): 4015–25. August 2000. doi:10.1093/emboj/19.15.4015. PMID 10921882.
- ↑ "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- ↑ "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. September 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- ↑ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=30011.
- ↑ 6.0 6.1 6.2 6.3 6.4 "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications 278 (1): 167–74. November 2000. doi:10.1006/bbrc.2000.3760. PMID 11071869. Bibcode: 2000BBRC..278..167W. https://zenodo.org/record/1229524.
- ↑ "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal 19 (15): 4015–25. August 2000. doi:10.1093/emboj/19.15.4015. PMID 10921882.
- ↑ 8.0 8.1 "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling 12 (11–12): 769–79. December 2000. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
- ↑ 9.0 9.1 9.2 "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. March 2002. doi:10.1038/416187a. PMID 11894096. Bibcode: 2002Natur.416..187P.
- ↑ 10.0 10.1 10.2 10.3 "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature 416 (6877): 183–7. March 2002. doi:10.1038/416183a. PMID 11894095. Bibcode: 2002Natur.416..183S.
- ↑ 11.0 11.1 11.2 "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry 277 (42): 39666–72. October 2002. doi:10.1074/jbc.M205535200. PMID 12177062.
- ↑ "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". The Journal of Biological Chemistry 278 (36): 34102–9. September 2003. doi:10.1074/jbc.M305264200. PMID 12829691.
Further reading
- "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN". The Journal of Biological Chemistry 273 (12): 6989–97. March 1998. doi:10.1074/jbc.273.12.6989. PMID 9507006.
- "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". The EMBO Journal 17 (24): 7320–36. December 1998. doi:10.1093/emboj/17.24.7320. PMID 9857189.
- "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl". Biochemical and Biophysical Research Communications 268 (2): 321–8. February 2000. doi:10.1006/bbrc.2000.2147. PMID 10679202. Bibcode: 2000BBRC..268..321T. https://zenodo.org/record/1229512.
- "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". The Journal of Biological Chemistry 275 (25): 19275–81. June 2000. doi:10.1074/jbc.M908994199. PMID 10858458.
- "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal 19 (15): 4015–25. August 2000. doi:10.1093/emboj/19.15.4015. PMID 10921882.
- "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications 278 (1): 167–74. November 2000. doi:10.1006/bbrc.2000.3760. PMID 11071869. Bibcode: 2000BBRC..278..167W. https://zenodo.org/record/1229524.
- "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling 12 (11–12): 769–79. December 2000. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
- "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization". Cytogenetics and Cell Genetics 93 (1–2): 133–4. 2001. doi:10.1159/000056966. PMID 11474197.
- "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature 416 (6877): 183–7. March 2002. doi:10.1038/416183a. PMID 11894095. Bibcode: 2002Natur.416..183S.
- "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. March 2002. doi:10.1038/416187a. PMID 11894096. Bibcode: 2002Natur.416..187P.
- "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry 277 (31): 28238–46. August 2002. doi:10.1074/jbc.M202783200. PMID 12029088.
- "Ruk is ubiquitinated but not degraded by the proteasome". European Journal of Biochemistry 269 (14): 3402–8. July 2002. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
- "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry 277 (42): 39666–72. October 2002. doi:10.1074/jbc.M205535200. PMID 12177062.
- "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proceedings of the National Academy of Sciences of the United States of America 99 (19): 12191–6. September 2002. doi:10.1073/pnas.192462299. PMID 12218189. Bibcode: 2002PNAS...9912191H.
- "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues". Gene 295 (1): 13–17. July 2002. doi:10.1016/S0378-1119(02)00821-1. PMID 12242006.
- "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities". International Immunology 15 (3): 313–29. March 2003. doi:10.1093/intimm/dxg032. PMID 12618476.
- "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". The Journal of Biological Chemistry 278 (25): 22396–403. June 2003. doi:10.1074/jbc.M302540200. PMID 12690097.
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