Biology:Valencene synthase

From HandWiki
Short description: Class of enzymes
Valencene synthase
Identifiers
EC number4.2.3.73
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Valencene synthase (EC 4.2.3.73) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming).[1] It is a terpene cyclase enzyme responsible for the biosynthesis of valencene, a sesquiterpene, using farnesyl pyrophosphate as its substrate. The first such enzyme was isolated using orange cDNA.[2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] (+)-valencene + diphosphate

The recombinant enzyme from Vitis vinifera forms (+)-valencene and (-)-7-epi-α-selinene.

References

  1. "Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries". Phytochemistry 65 (19): 2649–59. October 2004. doi:10.1016/j.phytochem.2004.08.017. PMID 15464152. 
  2. "Citrus fruit flavor and aroma biosynthesis: isolation, functional characterization, and developmental regulation of Cstps1, a key gene in the production of the sesquiterpene aroma compound valencene". The Plant Journal (Blackwell Publishing Ltd.) 36 (5): 664–74. December 2003. doi:10.1046/j.1365-313x.2003.01910.x. PMID 14617067. 

External links