Chemistry:BPC-157
From HandWiki
Short description: Pentadecapeptide
BPC-157 (also known as PL 14736) is a pentadecapeptide. It has the amino acid sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val.[1] This peptide has a molecular formula of C62H98N16O22. The PUBCHEM ID is CID 9941957.[2]
The peptide is banned by the World Anti-Doping Agency in 2022 under the S0 category of non-exempt substances.[3]
Research
There are some tentative pre-clinical studies on animals and in vitro suggesting possible benefit in wound healing and bowel disorders although all of these studies come from a single research group.[4][5]
Unapproved marketing
BPC 157 is marketed in functional medicine, although, FDA approval is not issued yet for it to be used in standard medicine.[6]
References
- ↑ Jelovac, Nikola; Sikiric, Predrag; Rucman, Rudolf; Petek, Marijan; Marovic, Anton; Perovic, Darko; Seiwerth, Sven; Mise, Stjepan et al. (1999). "Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats". European Journal of Pharmacology 379 (1): 19–31. doi:10.1016/S0014-2999(99)00486-0. PMID 10499368.
- ↑ "PUBCHEM" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/9941957#section=Names-and-Identifiers.
- ↑ "2022 Prohibited List: SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION)". WADA. https://www.wada-ama.org/sites/default/files/2022-01/2022list_draft_explanatory_list_en_0.pdf.
- ↑ Sikiric, P.; Seiwerth, S.; Brcic, L.; Blagaic, A. B.; Zoricic, I.; Sever, M.; Klicek, R.; Radic, B. et al. (2006). "Stable gastric pentadecapeptide BPC 157 in trials for inflammatory bowel disease (PL-10, PLD-116, PL 14736, Pliva, Croatia). Full and distended stomach, and vascular response.". Inflammopharmacology 14 (5–6): 214–21. doi:10.1007/s10787-006-1531-7. PMID 17186181.
- ↑ Cerovecki, Tomislav; Bojanic, Ivan; Brcic, Luka; Radic, Bozo; Vukoja, Ivan; Seiwerth, Sven; Sikiric, Predrag (September 2010). "Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat". Journal of Orthopaedic Research 28 (9): 1155–1161. doi:10.1002/jor.21107. ISSN 1554-527X. PMID 20225319.
- ↑ Sikiric, P; Seiwerth, S; Rucman, R; Kolenc, D; Vuletic, LB; Drmic, D; Grgic, T; Strbe, S et al. (2016). "Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.". Current Neuropharmacology 14 (8): 857–865. doi:10.2174/1570159x13666160502153022. PMID 27138887.
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