Chemistry:HPTP
From HandWiki
HPTP is a monoaminergic neurotoxin related to MPTP.[1][2][3][4] It is the dehydration product of haloperidol.[1][2][4] The agent is specifically a dopaminergic and serotonergic neurotoxin.[1] HPTP is a prodrug of HPP+, which mediates its monoaminergic neurotoxicity.[1][2][4] This is analogous to how MPP+ mediates the neurotoxicity of MPTP.[1][2][4] Other related compounds include RHPTP and RHPP+.[5]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons". Handbook of Neurotoxicity. Cham: Springer International Publishing. 2022. pp. 159–198. doi:10.1007/978-3-031-15080-7_53. ISBN 978-3-031-15079-1.
- ↑ 2.0 2.1 2.2 2.3 Igarashi, Kazuo (1998). "The Possible Role of an Active Metabolite Derived from the Neuroleptic Agent Haloperidol in Drug-Induced Parkinsonism". Journal of Toxicology: Toxin Reviews 17 (1): 27–38. doi:10.3109/15569549809006488. ISSN 0731-3837.
- ↑ "[The neurotoxicity of pyridinium metabolites of haloperidol]" (in Polish). Postepy Higieny I Medycyny Doswiadczalnej 69: 1169–1175. October 2015. doi:10.5604/17322693.1175009. PMID 26561842.
- ↑ 4.0 4.1 4.2 4.3 "Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins". Pol J Pharmacol 51 (1): 31–38. 1999. PMID 10389142.
- ↑ "Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites". Chem Res Toxicol 19 (7): 914–920. July 2006. doi:10.1021/tx0600090. PMID 16841959.
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