Chemistry:IGF-1 LR3

From HandWiki
Short description: Synthetic protein
IGF-1 LR3
Clinical data
Other namesLong R3-IGF-1;
IGF-1 Long R3
Routes of
administration
Injection
ATC code
  • None
Pharmacokinetic data
Elimination half-life56-72 hours
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
FormulaC400H625N111O115S9
Molar mass9117.60 g·mol−1

Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1).[1][2] It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), for a total of 83 amino acids (relative to the 70 of IGF-1).[2] The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability.[1][2] As a result, it is approximately three times more potent than IGF-1,[3] and possesses a significantly longer half-life of about 20–30 hours (relative to IGF-1's half-life of about 12–15 hours).[4]

The amino acid sequence of IGF-1 LR3 is MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA.[5]

See also

References

  1. 1.0 1.1 "Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection". J. Endocrinol. 150 (1): 77–84. 1996. doi:10.1677/joe.0.1500077. PMID 8708565. 
  2. 2.0 2.1 2.2 "IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms". J. Endocrinol. 175 (1): 19–31. 2002. doi:10.1677/joe.0.1750019. PMID 12379487. 
  3. "Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats". Biochem. J. 282 ( Pt 1) (Pt 1): 91–7. 1992. doi:10.1042/bj2820091. PMID 1371669. 
  4. "IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype". Am. J. Pathol. 178 (2): 924–34. 2011. doi:10.1016/j.ajpath.2010.10.007. PMID 21281823. 
  5. Mario Thevis (13 December 2010). Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays. John Wiley & Sons. pp. 252–. ISBN 978-1-118-03514-6. https://books.google.com/books?id=dWHQMev5mHwC&pg=PA252.