Medicine:Adenovirus vaccine
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| Vaccine description | |
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| Target disease | Adenovirus |
| Type | Live virus |
| Clinical data | |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | By mouth |
| ATC code |
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| Legal status | |
| Legal status | |
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An adenovirus vaccine is a vaccine against adenovirus infection.[3] According to American CDC, "There is currently no adenovirus vaccine available to the general public.[4]
It should not be confused with the strategy of using adenovirus as a viral vector to develop vaccines for other pathogens, or as a general gene carrier.[5][6][7]
US military
It was used by the United States military from 1971 to 1999, but was discontinued when the only manufacturer stopped production.[8][9] This vaccine elicited immunity to adenovirus serotypes 4 and 7,[10] the serotypes most often associated with acute respiratory disease. On 16 March 2011, the U.S. Food and Drug Administration approved an adenovirus vaccine manufactured by Teva Pharmaceuticals under contract to the U.S. Army.[11] This vaccine is essentially the same as the one used from 1971 to 1999. On 24 October 2011, the military services began administering the new adenovirus vaccine to recruits during basic training.[12]
The vaccine is orally administered and consists of live (not attenuated) virus. The tablets are coated, so that the virus passes the stomach and infects the intestines, where the immune response is raised.[13]
References
- ↑ "Adenovirus Type 4 and Type 7 Vaccine, Live kit". 26 July 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c7d0b43c-7250-4809-8a05-fcde5862f076.
- ↑ "Adenovirus Type 4 and Type 7 Vaccine, Live, Oral". 15 October 2019. https://www.fda.gov/vaccines-blood-biologics/vaccines/adenovirus-type-4-and-type-7-vaccine-live-oral.
- ↑ "Oral adenoviral-based vaccines: historical perspective and future opportunity". Expert Rev Vaccines 7 (1): 25–31. February 2008. doi:10.1586/14760584.7.1.25. PMID 18251691.
- ↑ "Adenovirus Vaccine Information Statement | CDC" (in en-us). 2023-04-27. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/adenovirus.html.
- ↑ Doolan, Denise L., ed (2008). "Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice". PLOS ONE 3 (10): e3548. doi:10.1371/journal.pone.0003548. PMID 18958172. Bibcode: 2008PLoSO...3.3548C.
- ↑ "Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications". Virus Res. 132 (1–2): 1–14. March 2008. doi:10.1016/j.virusres.2007.10.005. PMID 18036698.
- ↑ "Adenoviruses as vaccine vectors". Mol. Ther. 10 (4): 616–29. October 2004. doi:10.1016/j.ymthe.2004.07.013. PMID 15451446.
- ↑ "Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999-2004". Vaccine 24 (15): 2835–42. April 2006. doi:10.1016/j.vaccine.2005.12.062. PMID 16480793.
- ↑ "Vaccine Trials For "Boot Camp Crud" May Help 20 Percent of Recruits". http://www.navy.mil/search/display.asp?story_id=26369.
- ↑ Centers for Disease Control and Prevention (CDC) (July 2001). "Two fatal cases of adenovirus-related illness in previously healthy young adults--Illinois, 2000". MMWR Morb. Mortal. Wkly. Rep. 50 (26): 553–5. PMID 11456329.
- ↑ Malarkey MA, Baylor NW. FDA approval letter dated 16 March 2011.
- ↑ "Safety evaluation of adenovirus type 4 and type 7 vaccine live, oral in military recruits". Vaccine 34 (38): 4558–4564. 31 August 2016. doi:10.1016/j.vaccine.2016.07.033. PMID 27475474.
- ↑ Package insert for Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, fda.gov, accessed 9 July 2020
External links
- "Adenovirus Vaccine Information Statement". U.S. Centers for Disease Control and Prevention (CDC). January 2020. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/adenovirus.html.
- Adenovirus Vaccines at the US National Library of Medicine Medical Subject Headings (MeSH)
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