Medicine:Pneumococcal polysaccharide vaccine

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Short description: Pneumonia vaccine
Pneumococcal polysaccharide vaccine
Pneumovax 23.jpg
Vaccine description
Target disease23 serotypes of Streptococcus pneumoniae
Typepolysaccharide
Clinical data
Trade namesPneumovax 23
Other namesPPSV, PPV-23, PPSV23
AHFS/Drugs.comMonograph
MedlinePlusa607022
License data
Pregnancy
category
Routes of
administration		Intramuscular
ATC code
Legal status
Legal status
Identifiers
ChemSpider
  • none
KEGG
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Pneumococcal polysaccharide vaccine, sold under the brand name Pneumovax 23, is a pneumococcal vaccine that is used for the prevention of pneumococcal disease caused by the 23 serotypes of Streptococcus pneumoniae contained in the vaccine as capsular polysaccharides.[2] It is given by intramuscular or subcutaneous injection.[2]

The polysaccharide antigens were used to induce type-specific antibodies that enhanced opsonization, phagocytosis, and killing of Streptococcus pneumoniae (pneumococcal) bacteria by phagocytic immune cells. The pneumococcal polysaccharide vaccine is widely used in high-risk adults.[4]

First used in 1945, the tetravalent vaccine was not widely distributed, since its deployment coincided with the discovery of penicillin.[5] In the 1970s, Robert Austrian championed the manufacture and distribution of a 14-valent pneumococcal polysaccharide vaccine.[6][7] This evolved in 1983 to a 23-valent formulation (PPSV23). A significant breakthrough affecting the burden of pneumococcal disease was the licensing of a protein conjugate heptavalent vaccine (PCV7) beginning in February 2000.[8]

Medical uses

In the United States, pneumococcal vaccine, polyvalent is indicated for active immunization for the prevention of pneumococcal disease caused by the 23 serotypes contained in the vaccine (1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19F, 19A, 20, 22F, 23F, and 33F).[3][2] It is approved for use in people 50 years of age or older and people aged two years of age or older who are at increased risk for pneumococcal disease.[2][9] The World Health Organization (WHO) recommendations are similar. The WHO does not recommend use of pneumococcal polysaccharide vaccine in routine childhood immunization programs.[10][11] The recommendations in the UK are similar, but include people with occupational hazards.[12]

Pneumococcal vaccine may be beneficial to control exacerbations of chronic obstructive pulmonary disease (COPD).[13]

The pneumococcal polysaccharide vaccine is important for those with HIV/AIDS. In Canadian patients infected with HIV, the vaccine has been reported to decrease the incidence of invasive pneumococcal disease from 768 per 100,000 person–years to 244 per 100,000 patient–years.[4] Because of the low level of evidence for benefit, 2008 WHO guidelines do not recommend routine immunization with PPV-23 for HIV patients, and suggests preventing pneumococcal disease indirectly with trimethoprim–sulfamethoxazole chemoprophylaxis and antiretrovirals.[10] While the U.S. Centers for Disease Control and Prevention (CDC) recommends immunization in all patients infected with HIV.[14]

Adverse events

The most common adverse reactions (reported in more than 10% of subjects vaccinated with pneumococcal polysaccharide vaccine in clinical trials) were: pain, soreness or tenderness at the site of injection (60.0%), injection-site swelling or temporary thickening or hardening of the skin (20.3%), headache (17.6%), injection-site redness (16.4%), weakness and fatigue (13.2%), and muscle pain (11.9%).[2]

Vaccination schedule

Adults and children over two years of age

The 23-valent vaccine (for example, Pneumovax 23) is effective against 23 different pneumococcal capsular types (serotypes 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F), and so covers 90 percent of the types found in pneumococcal bloodstream infections.[2]

Young children

Children under the age of two years fail to mount an adequate response to the 23-valent adult vaccine, and instead a 13-valent pneumococcal conjugated vaccine (PCV13; for example, Prevnar 13) is used instead. PCV13 replaced PCV7, adding six new serotypes to the vaccine. While this covers only thirteen strains out of more than ninety strains, these thirteen strains caused 80–90 percent of cases of severe pneumococcal disease in the U.S. before introduction of the vaccine, and it is considered to be nearly 100 percent effective against these strains.[15]

Special risk-groups
Children at special risk (e.g., sickle cell disease and those without a functioning spleen) require additional protection using the PCV13, with the more extensive PPSV-23 given after the second year of life or two months after the PCV13 dose:
Vaccination schedule for children at special risk in the UK[16]
Age 2–6 months 7–11 months 12–23 months
PCV13 3 × monthly dose 2 × monthly dose 2 doses, 2 months apart
Further dose in second year of life
PPSV-23 Single dose after second year of life, 2 months after PCV13

References

  1. ↑ "Pneumococcal 23-polyvalent vaccine (Pneumovax 23) Use During Pregnancy". 7 October 2019. https://www.drugs.com/pregnancy/pneumococcal-23-polyvalent-vaccine.html. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "Pneumovax 23- pneumococcal vaccine polyvalent injection, solution". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bb362a20-6d91-4ae8-bebb-9ee8b2591814. 
  3. ↑ 3.0 3.1 "Pneumovax 23 - Pneumococcal Vaccine, Polyvalent". 28 October 2021. https://www.fda.gov/vaccines-blood-biologics/vaccines/pneumovax-23-pneumococcal-vaccine-polyvalent.  This article incorporates text from this source, which is in the public domain.
  4. ↑ 4.0 4.1 "The persisting burden of invasive pneumococcal disease in HIV patients: an observational cohort study". BMC Infectious Diseases 11: 314. November 2011. doi:10.1186/1471-2334-11-314. PMID 22078162. 
  5. ↑ "Prevention of Pneumococcal Pneumonia by Immunization with Specific Capsular Polysaccharides". The Journal of Experimental Medicine 82 (6): 445–465. November 1945. doi:10.1084/jem.82.6.445. PMID 19871511. 
  6. ↑ "Prevention of pneumococcal pneumonia by vaccination". Transactions of the Association of American Physicians 89: 184–194. 1976. PMID 14433. 
  7. ↑ "Robert Austrian: 1917-2007". Clin Infect Dis 45: 2–3. 2007. doi:10.1086/520068. 
  8. ↑ "Immunogenicity and safety of pneumococcal 7-valent conjugate vaccine (diphtheria CRM(197) protein conjugate; Prevenar ) in Korean infants: differences that are found in Asian children". Vaccine 25 (45): 7858–7865. November 2007. doi:10.1016/j.vaccine.2007.08.022. PMID 17931753. 
  9. ↑ "Pneumococcal Vaccination - What You Should Know". 6 December 2017. https://www.cdc.gov/vaccines/vpd/pneumo/public/index.html. 
  10. ↑ 10.0 10.1 "23-valent pneumococcal polysaccharide vaccine : WHO position paper". Wkly. Epidemiol. Rec. 83 (42): 373–84. 2008. PMID 18927997. 
  11. ↑ "World Health Organization. Pneumococcal vaccines". https://www.who.int/vaccines/en/pneumococcus.shtml. 
  12. ↑ "Who should have the pneumococcal vaccine?". NHS. 2019. https://www.nhs.uk/conditions/vaccinations/when-is-pneumococcal-vaccine-needed/. 
  13. ↑ "Pneumococcal vaccination and chronic respiratory diseases". Int J Chron Obstruct Pulmon Dis 12: 3457–3468. 2017. doi:10.2147/COPD.S140378. PMID 29255353. 
  14. ↑ "Pneumococcal Vaccine Timing for Adults". 16 March 2020. https://www.cdc.gov/vaccines/vpd/pneumo/downloads/pneumo-vaccine-timing.pdf. 
  15. ↑ Childhood Pneumococcal Disease – information on the disease and the Prevnar vaccine, from the Victoria State (Australia) government. [|permanent dead link|dead link}}]
  16. ↑ "Pneumococcal: the green book, chapter 25". Immunisation against infectious disease. Public Health England. 2013. Gateway 2017624. https://www.gov.uk/government/publications/pneumococcal-the-green-book-chapter-25. 

Further reading

External links




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