Chemistry:Ovandrotone albumin
| Combination of | |
|---|---|
| Ovandrotone | Androstane steroid |
| Human serum albumin | Serum protein |
| Clinical data | |
| Trade names | Fecundin, Ovastim |
| Other names | Polyandroalbumin; GR-33207; Ovandrotone:human serum albumin conjugate |
| AHFS/Drugs.com | Monograph |
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| Legal status | |
| Legal status |
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Ovandrotone albumin (INN, BAN) (brand names Fecundin, Ovastim),[1] also known as polyandroalbumin, as well as ovandrotone:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.[2][3][4][5] It is a conjugate of ovandrotone (androstenedione-7α-carboxyethylthioether)[6] and human serum albumin.[5] The drug was developed by 1981 and was introduced in Australia and New Zealand in 1983.[4][7]
Ovandrotone albumin produces transient immunity against androstenedione,[8] and the generation of antibodies against androstenedione presumably decreases circulating levels of androstenedione.[7] This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.[4] Indeed, ovandrotone albumin has been found to significantly increase luteinizing hormone levels throughout the estrous cycle in ewes.[4]
See also
References
- ↑ Yields of Farmed Species: Constraints and Opportunities in the 21st Century. Nottingham University Press. 1 January 2005. p. 55. ISBN 978-1-904761-23-5. https://books.google.com/books?id=gnUbAQAAMAAJ.
- ↑ The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. p. 908. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA908.
- ↑ "Effects of Antibodies to Steroid Hormones on Reproductive Events of Sheep and Cattle". Immunological Approaches to Contraception and Promotion of Fertility. 1986. pp. 351–366. doi:10.1007/978-1-4684-5140-5_38. ISBN 978-1-4684-5142-9.
- ↑ 4.0 4.1 4.2 4.3 Carnegie, Patrick R. (1988). "Autoimmunization Against Hormones: A New Strategy in Animal Production". Anti-Idiotypes, Receptors, and Molecular Mimicry. pp. 245–254. doi:10.1007/978-1-4612-3734-1_15. ISBN 978-1-4612-8325-6.
- ↑ 5.0 5.1 International Nonproprietary Names (INN) for biological and biotechnological substances
- ↑ Journal of Animal Science. American Society of Animal Science. 1991. pp. 3931–3932. https://books.google.com/books?id=nbqzAAAAIAAJ.
- ↑ 7.0 7.1 Embryonic Mortality in Farm Animals. Springer Science & Business Media. 6 December 2012. pp. 172–. ISBN 978-94-009-5038-2. https://books.google.com/books?id=QKFyBgAAQBAJ&pg=PA172.
- ↑ Reproduction in Sheep. Cambridge University Press. 1984.
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