Medicine:Organomegaly

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Short description: Medical condition in which organs are larger than normal

Organomegaly is the abnormal enlargement of organs. For example, cardiomegaly is enlargement of the heart. Visceromegaly is the enlargement of abdominal organs.[1] Examples of visceromegaly are enlarged liver (hepatomegaly), spleen (splenomegaly), stomach, kidneys, and pancreas.

Definitions for various organs

Values refer to adults unless otherwise specified.

Organ Term for enlargement Cutoff for definition
Abdominal aorta Ectasia or mild dilation

>2.0 cm and <3.0 cm[2]

Abdominal aortic aneurysm
  • Moderate AAA: 3.0–5.0 cm[2]
  • Large or severe AAA: >5.0[2] or 5.5.[3] cm
Common bile duct Dilatation
  • Mild dilatation:[4] 8–12 mm
  • Moderate dilatation:[4] 12–16 mm
  • Severe dilatation:[4] 16–20 mm
  • Extremely severe dilatation:[4] >20 mm
Gallbladder Wall thickening 3 mm wall thickness[5]
Hydrops Greater than 5 cm transverse dimension[6]
Heart Cardiomegaly
  • Medical imaging: Indicated by cardiothoracic ratio over 0.5.[7]
  • Autopsy: Cardiomegaly has been suggested when the heart weighs more than >399 grams in women and >449 grams in men.[8]
Large intestine Dilation

Upper limit of normal range of diameter:[9]

Wall thickening Wall thickness 5 mm[10]
Kidneys Enlargement
Sex Upper limit of standard reference range
Right kidney Left kidney
Men[12] 160 g (5.6 oz) 175 g (6.2 oz)
Women[13] 175 g (6.2 oz) 190 g (6.7 oz)
Liver Hepatomegaly
  • Medical imaging: Longitudinal axis > 15.5 cm at the hepatic midline, or > 16.0 cm at the midclavicular line[14]
  • Autopsy: Weight over upper limit of standard reference range, of 1,860 g (4.10 lb) in men[12] and 1,770 g (3.90 lb) in women.[13]
Lymph nodes Lymphadenopathy Generally 10 mm[15][16]
(see Lymphadenopathy) for detailed values)
Renal pelvis Part of hydronephrosis grading 4 – 20 mm:
  • Fetal: Anteroposterior diameter of less than 4 mm in fetuses up to 32 weeks of gestational age and 7 mm afterwards.[17]
  • Adults: cutoff values defined differently by different sources, with anteroposterior diameters ranging between 10 and 20 mm.[18] About 13% of normal healthy adults have a transverse pelvic diameter of over 10 mm.[19]
Prostate Prostatomegaly Volume over 30 cm3.
Pulmonary artery Dilation >29 mm[20]
Small intestine Dilation
  • Mild: 2.5–2.9 cm[23]
  • Moderate: 3-4 cm[23]
  • Severe: >4 cm[23]
  • 3 cm on abdominal X-rays[21][24] (Projectional radiography confers a geometric magnification compared to CT[25])
Wall thickening 3–5 mm[26]
Spleen Splenomegaly
  • Moderate splenomegaly: the largest dimension is between 11–20 cm[27]
  • Severe splenomegaly: the largest dimension is greater than 20 cm[27]
  • Autopsy: Weight over upper limit of standard reference range, of 230 g (8.1 oz)[12][13]
Thoracic aorta Dilation Diameters:
  • >3.5 cm generally[30]

Upper limits of standard reference range:

  • Ascending aorta:
  • 3.3 cm in small young individuals[31]
  • 4.3 cm among large elderly individuals.[31]
  • Descending thoracic aorta,
  • 2.3 cm among small young individuals[31]
  • 3.2 cm among large elderly individuals.[31]
Thoracic aortic aneurysm Diameter:
  • > 4.5 cm (US)[30]
  • > 4.0 cm (Korea)[32]
Testis Enlargement 5 cm (long axis) x 3 cm (short axis)[33]
Ureter Megaureter 6[34] or 7[35] mm
Urinary bladder Wall thickening 3–5 mm thick, and < 3 mm when well distended.[36]

References

  1. ↑ "Visceromegaly on Medline Plus". https://www.nlm.nih.gov/medlineplus/ency/article/002340.htm. 
  2. ↑ 2.0 2.1 2.2 Page 56 in: Philip Lumb (2014). Critical Care Ultrasound E-Book. Elsevier Health Sciences. ISBN 9780323278171. 
  3. ↑ "Screening for abdominal aortic aneurysms: single centre randomised controlled trial". BMJ 330 (7494): 750. Apr 2005. doi:10.1136/bmj.38369.620162.82. PMID 15757960. 
  4. ↑ 4.0 4.1 4.2 4.3 Yunfu Lv, Wan Yee Lau, Haiying Wu, Shunwu Chang, NingLiu, Yejuan Li, Jie Deng (2015). "Etiological Causes of Intrahepatic and Extrahepatic Bile Duct Dilatation". International Journal of New Technology and Research (IJNTR) 1 (8). https://www.ijntr.org/download_data/IJNTR01080032.pdf. 
  5. ↑ van Breda Vriesman, Adriaan C.; Engelbrecht, Marc R.; Smithuis, Robin H. M.; Puylaert, Julien B. C. M. (2007). "Diffuse Gallbladder Wall Thickening: Differential Diagnosis". American Journal of Roentgenology 188 (2): 495–501. doi:10.2214/AJR.05.1712. ISSN 0361-803X. PMID 17242260. 
  6. ↑ Page 256 in Neil Kaplowitz (1996). Liver and Biliary Diseases. Williams & Wilkins. ISBN 9780683045451. 
  7. ↑ Justin, M; Zaman, S; Sanders, J.; Crook, A. M; Feder, G.; Shipley, M.; Timmis, A.; Hemingway, H. (2007). "Cardiothoracic ratio within the "normal" range independently predicts mortality in patients undergoing coronary angiography". Heart 93 (4): 491–494. doi:10.1136/hrt.2006.101238. ISSN 1355-6037. PMID 17164481. 
  8. ↑ Tracy, Richard Everett (2011). "Association of Cardiomegaly with Coronary Artery Histopathology and its Relationship to Atheroma". Journal of Atherosclerosis and Thrombosis 18 (1): 32–41. doi:10.5551/jat.5090. ISSN 1880-3873. PMID 20953090. 
  9. ↑ "Deficient Pms2, ERCC1, Ku86, CcOI in field defects during progression to colon cancer". J Vis Exp (41). 2010. doi:10.3791/1931. PMID 20689513. 
  10. ↑ Fernandes, Teresa; Oliveira, Maria I.; Castro, Ricardo; Araújo, Bruno; Viamonte, Bárbara; Cunha, Rui (2014). "Bowel wall thickening at CT: simplifying the diagnosis". Insights into Imaging 5 (2): 195–208. doi:10.1007/s13244-013-0308-y. ISSN 1869-4101. PMID 24407923. 
  11. ↑ Yuranga Weerakkody; Henry Knipe. "Kidneys". https://radiopaedia.org/articles/kidneys. 
  12. ↑ 12.0 12.1 12.2 Molina, D. Kimberley; DiMaio, Vincent J.M. (2012). "Normal Organ Weights in Men". The American Journal of Forensic Medicine and Pathology 33 (4): 368–372. doi:10.1097/PAF.0b013e31823d29ad. ISSN 0195-7910. PMID 22182984. 
  13. ↑ 13.0 13.1 13.2 Molina, D. Kimberley; DiMaio, Vincent J. M. (2015). "Normal Organ Weights in Women". The American Journal of Forensic Medicine and Pathology 36 (3): 182–187. doi:10.1097/PAF.0000000000000175. ISSN 0195-7910. PMID 26108038. 
  14. ↑ Vermelho, Marli Batista Fernandes; Correia, Ademir Silva; Michailowsky, Tânia Cibele de Almeida; Suzart, Elizete Kazumi Kuniyoshi; Ibanês, Aline Santos; Almeida, Lanamar Aparecida; Khoury, Zarifa; Barba, Mário Flores (2015). "Abdominal alterations in disseminated paracoccidioidomycosis: computed tomography findings". Radiologia Brasileira 48 (2): 81–85. doi:10.1590/0100-3984.2013.0025. ISSN 0100-3984. PMID 25987748. 
  15. ↑ Ganeshalingam, Skandadas; Koh, Dow-Mu (2009). "Nodal staging". Cancer Imaging 9 (1): 104–11. doi:10.1102/1470-7330.2009.0017. ISSN 1470-7330. PMID 20080453. 
  16. ↑ Schmidt Júnior, Aurelino Fernandes; Rodrigues, Olavo Ribeiro; Matheus, Roberto Storte; Kim, Jorge Du Ub; Jatene, Fábio Biscegli (2007). "Distribuição, tamanho e número dos linfonodos mediastinais: definições por meio de estudo anatômico". Jornal Brasileiro de Pneumologia 33 (2): 134–140. doi:10.1590/S1806-37132007000200006. ISSN 1806-3713. PMID 17724531. 
  17. ↑ Page 189 in: V. D'Addario (2014). Donald School Basic Textbook of Ultrasound in Obstetrics & Gynecology. JP Medical Ltd. ISBN 9789351523376. 
  18. ↑ Page 78 in: Justin Bowra, Russell E (2011). Emergency Ultrasound Made Easy, Edition 2. Elsevier Health Sciences. ISBN 9780702048722. 
  19. ↑ "Sonographic evaluation of renal appearance in 665 adult volunteers. Correlation with age and obesity". Acta Radiol 34 (5): 482–5. 1993. doi:10.3109/02841859309175388. PMID 8369185. 
  20. ↑ Frank Gaillard. "Pulmonary hypertension". https://radiopaedia.org/articles/pulmonary-hypertension-1. 
  21. ↑ 21.0 21.1 Ali Nawaz Khan (2016-09-22). "Small-Bowel Obstruction Imaging". http://emedicine.medscape.com/article/374962-overview. 
  22. ↑ Gazelle, G S; Goldberg, M A; Wittenberg, J; Halpern, E F; Pinkney, L; Mueller, P R (1994). "Efficacy of CT in distinguishing small-bowel obstruction from other causes of small-bowel dilatation.". American Journal of Roentgenology 162 (1): 43–47. doi:10.2214/ajr.162.1.8273687. ISSN 0361-803X. PMID 8273687. 
  23. ↑ 23.0 23.1 23.2 Kuang, Lian-qin; Zhao, Da-wei; Cheng, Cheng; Wang, Yi (2016). "Prediction of Small Bowel Obstruction Caused by Bezoars Using Risk Factor Categories on Multidetector Computed Tomographic Findings". BioMed Research International 2016: 1–9. doi:10.1155/2016/6569103. ISSN 2314-6133. PMID 27403434. 
  24. ↑ "Abdominal X-ray - Abnormal bowel gas pattern". http://www.radiologymasterclass.co.uk/tutorials/abdo/abdomen_x-ray_abnormalities/pathology_small_bowel_obstruction. 
  25. ↑ Pérez, M. A.; Affatato, Saverio; Zanini, Filippo; Carmignato, Simone (2017). "Micro X-Ray Computed Tomography Mass Loss Assessment of Different UHMWPE: A Hip Joint Simulator Study on Standard vs. Cross-Linked Polyethylene". PLOS ONE 12 (1): e0170263. doi:10.1371/journal.pone.0170263. ISSN 1932-6203. PMID 28107468. Bibcode: 2017PLoSO..1270263A. 
  26. ↑ Ali Nawaz Khan. "Small-Bowel Obstruction Imaging". http://emedicine.medscape.com/article/374962-overview.  Updated: Sep 22, 2016
  27. ↑ 27.0 27.1 27.2 Neetu Radhakrishnan (2018-07-25). Splenomegaly. http://emedicine.medscape.com/article/206208-overview.  Updated Apr. 2012 (referring the classification system to Poulin et al.
  28. ↑ Page 1964 in: Florian Lang (2009). Encyclopedia of Molecular Mechanisms of Disease. Springer Science & Business Media. ISBN 9783540671367. 
  29. ↑ Saboo, S S; Krajewski, K M; O'Regan, K N; Giardino, A; Brown, J R; Ramaiya, N; Jagannathan, J P (2012). "Spleen in haematological malignancies: spectrum of imaging findings". The British Journal of Radiology 85 (1009): 81–92. doi:10.1259/bjr/31542964. ISSN 0007-1285. PMID 22096219. 
  30. ↑ 30.0 30.1 Bret P Nelson (2015-10-01). "Thoracic Aneurysm". http://emedicine.medscape.com/article/761627-overview. 
  31. ↑ 31.0 31.1 31.2 31.3 Wolak, Arik; Gransar, Heidi; Thomson, Louise E.J.; Friedman, John D.; Hachamovitch, Rory; Gutstein, Ariel; Shaw, Leslee J.; Polk, Donna et al. (2008). "Aortic Size Assessment by Noncontrast Cardiac Computed Tomography: Normal Limits by Age, Gender, and Body Surface Area". JACC: Cardiovascular Imaging 1 (2): 200–209. doi:10.1016/j.jcmg.2007.11.005. ISSN 1936-878X. PMID 19356429. 
  32. ↑ Cho, In-Jeong; Jang, Sung-Yeol; Chang, Hyuk-Jae; Shin, Sanghoon; Shim, Chi Young; Hong, Geu-Ru; Chung, Namsik (2014). "Aortic Aneurysm Screening in a High-Risk Population: A Non-Contrast Computed Tomography Study in Korean Males with Hypertension". Korean Circulation Journal 44 (3): 162–9. doi:10.4070/kcj.2014.44.3.162. ISSN 1738-5520. PMID 24876857. 
  33. ↑ Page 559 in: John Pellerito, Joseph F Polak (2012). Introduction to Vascular Ultrasonography (6 ed.). Elsevier Health Sciences. ISBN 9781455737666. 
  34. ↑ "Enlarged ureter". 2015-12-18. http://www2.medizin.uni-greifswald.de/ki_chir/1/spectrum-of-care/thoracic-surgery/enlarged-ureter/. 
  35. ↑ Page 140 in: Mitchell E. Tublin (2015). Diagnostic Imaging: Genitourinary E-Book. Edition 3. Elsevier Health Sciences. ISBN 9780323400428. 
  36. ↑ Page 12 in: Uday Patel (2010). Imaging and Urodynamics of the Lower Urinary Tract. Springer Science & Business Media. ISBN 9781848828360. 



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