Physics:Paper spray ionization

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Short description: Technique used in mass spectrometry

Paper spray ionization is a technique used in mass spectrometry to produce ions from a sample to be analyzed. It is a variant of electrospray ionization.[1] The sample (for instance a few microlitres of blood or urine) is applied to a piece of paper and solvent is added. Then a high voltage is applied, which creates the ions to be analyzed with a mass spectrometer. The method, first described in 2010,[2] is relatively easy to use and can detect and measure the presence of various substances in the sample. This technique shows great potential for point-of-care clinical applications, in that important tests may be run and results obtained within a reasonable amount of time in proximity to the patient in a single visit.[3]

In 2017 it was reported that a test based on paper spray ionization mass spectrometry can detect cocaine use from a subject's fingerprint.[4] It was also used to detect pesticides from the surfaces of fruits. [5]

References

  1. ↑ Meher, Anil Kumar; Chen, Yu-Chie (2017). "Electrospray Modifications for Advancing Mass Spectrometric Analysis". Mass Spectrometry 6 (Spec Iss): S0057. doi:10.5702/massspectrometry.S0057. PMID 28573082. 
  2. ↑ Liu, Jiangjiang; Wang, He; Manicke, Nicholas E.; Lin, Jin-Ming; Cooks, R. Graham; Ouyang, Zheng (2010-03-15). "Development, characterization, and application of paper spray ionization". Analytical Chemistry 82 (6): 2463–2471. doi:10.1021/ac902854g. PMID 20158226. 
  3. ↑ Damon, Deidre E.; Davis, Kathryn M.; Moreira, Camila R.; Capone, Patricia; Cruttenden, Riley; Badu-Tawiah, Abraham K. (2016-02-02). "Direct Biofluid Analysis Using Hydrophobic Paper Spray Mass Spectrometry" (in en). Analytical Chemistry 88 (3): 1878–1884. doi:10.1021/acs.analchem.5b04278. ISSN 0003-2700. PMID 26730614. https://pubs.acs.org/doi/10.1021/acs.analchem.5b04278. 
  4. ↑ Glatter, Robert (September 23, 2017). "New Fingerprint Test Can Detect Cocaine Use In Seconds" (in en). Forbes. https://www.forbes.com/sites/robertglatter/2017/09/23/new-fingerprint-test-can-detect-cocaine-use-in-seconds/#1934b55c1f22. 
  5. ↑ Soparwalla, Santosh; Tadjimukhamedov, Fatkhulla K.; Wiley, Joshua S.; Ouyang, Zheng; Cooks, R. Graham (2011). "In situ analysis of agrochemical residues on fruit using ambient ionization on a handheld mass spectrometer". Analyst 136 (21): 4392–4396. doi:10.1039/C1AN15493A. PMID 21892448. 



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