Biology:Glucose-methanol-choline oxidoreductase family
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| GMC oxidoreductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for FAD dependent alcohol oxidases. | |||||||||
| Identifiers | |||||||||
| Symbol | GMC_oxred_N | ||||||||
| Pfam | PF00732 | ||||||||
| Pfam clan | CL0063 | ||||||||
| InterPro | IPR000172 | ||||||||
| PROSITE | PDOC00543 | ||||||||
| SCOP2 | 1gal / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 132 | ||||||||
| OPM protein | 1b4v | ||||||||
| |||||||||
| GMC oxidoreductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of cholesterol oxidase complexed with a steroid substrate. Implications for fad dependent alcohol oxidases. | |||||||||
| Identifiers | |||||||||
| Symbol | GMC_oxred_C | ||||||||
| Pfam | PF05199 | ||||||||
| InterPro | IPR007867 | ||||||||
| PROSITE | PDOC00543 | ||||||||
| SCOP2 | 1gal / SCOPe / SUPFAM | ||||||||
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In molecular biology, the glucose-methanol-choline oxidoreductase family (GMC oxidoreductase) is a family of enzymes with oxidoreductase activity.
The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases.[1][2] These enzymes include a variety of proteins; choline dehydrogenase (CHD) EC 1.1.99.1, methanol oxidase (MOX) EC 1.1.3.13 and cellobiose dehydrogenase EC 1.1.99.18[3] which share a number of regions of sequence similarities. They contain two conserved protein domains. The N-terminal domain corresponds to the FAD ADP-binding domain, the C-terminal domain is a steroid-binding domain.[4][5]
References
- ↑ Cavener DR (February 1992). "GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities". J. Mol. Biol. 223 (3): 811–4. doi:10.1016/0022-2836(92)90992-S. PMID 1542121.
- ↑ "Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases". Biochemistry 32 (43): 11507–15. November 1993. doi:10.1021/bi00094a006. PMID 8218217.
- ↑ "A critical review of cellobiose dehydrogenases". J. Biotechnol. 78 (2): 93–113. March 2000. doi:10.1016/S0168-1656(00)00206-6. PMID 10725534.
- ↑ "Crystal structure of pyranose 2-oxidase from the white-rot fungus Peniophora sp.". Biochemistry 43 (37): 11683–90. 2004. doi:10.1021/bi048609q. PMID 15362852.
- ↑ "Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution.". J Mol Biol 219 (3): 533–54. 1991. doi:10.1016/0022-2836(91)90192-9. PMID 2051487.
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