Biology:TRA (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@.[1][2][3] It contributes the alpha chain to the larger TCR protein (T-cell receptor).
References
- ↑ "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias". Science 229 (4715): 784–6. Sep 1985. doi:10.1126/science.3875152. PMID 3875152. Bibcode: 1985Sci...229..784E.
- ↑ "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia". EMBO J 4 (6): 1461–5. Oct 1985. doi:10.1002/j.1460-2075.1985.tb03803.x. PMID 3875483.
- ↑ "Entrez Gene: TRA@ T cell receptor alpha locus". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6955.
Further reading
- Kenwrick S; Levinson B; Taylor S et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
- Suzuki CK; Bonifacino JS; Lin AY et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP". J. Cell Biol. 114 (2): 189–205. doi:10.1083/jcb.114.2.189. PMID 1649196.
- "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. 1991. doi:10.1101/gad.5.5.880. PMID 1827423.
- "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex". Eur. J. Immunol. 20 (2): 299–305. 1990. doi:10.1002/eji.1830200211. PMID 2138083.
- Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood 74 (3): 1073–83. doi:10.1182/blood.V74.3.1073.1073. PMID 2546634.
- "Mitogenic lectins bind to the antigen receptor on human lymphocytes". Eur. J. Immunol. 19 (2): 389–96. 1989. doi:10.1002/eji.1830190225. PMID 2703017.
- Yanagi Y; Chan A; Chin B et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4. doi:10.1073/pnas.82.10.3430. PMID 3873654. Bibcode: 1985PNAS...82.3430Y.
- Sim GK; Yagüe J; Nelson J et al. (1985). "Primary structure of human T-cell receptor alpha-chain". Nature 312 (5996): 771–5. doi:10.1038/312771a0. PMID 6440030.
- "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes". Immunity 2 (4): 391–9. 1995. doi:10.1016/1074-7613(95)90147-7. PMID 7719941.
- "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains". Eur. J. Immunol. 24 (1): 84–92. 1994. doi:10.1002/eji.1830240114. PMID 8020575.
- "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro". Genes Dev. 11 (5): 629–39. 1997. doi:10.1101/gad.11.5.629. PMID 9119227.
- "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model". Eur. J. Immunol. 28 (1): 12–21. 1998. doi:10.1002/(SICI)1521-4141(199801)28:01<12::AID-IMMU12>3.0.CO;2-9. PMID 9485181.
- Ding YH; Smith KJ; Garboczi DN et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids". Immunity 8 (4): 403–11. doi:10.1016/S1074-7613(00)80546-4. PMID 9586631.
- Kirchgessner H; Dietrich J; Scherer J et al. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMID 11390434.
- Shelton JG; Gülland S; Nicolson K et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits". Mol. Immunol. 38 (4): 259–65. doi:10.1016/S0161-5890(01)00062-1. PMID 11566319.
- Pietra G; Romagnani C; Falco M et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition". Eur. J. Immunol. 31 (12): 3687–93. doi:10.1002/1521-4141(200112)31:12<3687::AID-IMMU3687>3.0.CO;2-C. PMID 11745389.
- "Structure of a Complex of the Human α/β T Cell Receptor (TCR) HA1.7, Influenza Hemagglutinin Peptide, and Major Histocompatibility Complex Class II Molecule, HLA-DR4 (DRA0101 and DRB10401): Insight into TCR Cross-Restriction and Alloreactivity". J. Exp. Med. 195 (5): 571–81. 2002. doi:10.1084/jem.20011194. PMID 11877480.
- García P; Llano M; de Heredia AB et al. (2002). "Human T cell receptor-mediated recognition of HLA-E". Eur. J. Immunol. 32 (4): 936–44. doi:10.1002/1521-4141(200204)32:4<936::AID-IMMU936>3.0.CO;2-M. PMID 11920559.
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