Biology:LILRA2
 Generic protein structure example |
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[1][2][3]
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][3]
Function
LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[4]
See also
References
- ↑ "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol 27 (3): 660–5. Apr 1997. doi:10.1002/eji.1830270313. PMID 9079806.
- ↑ "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. Apr 1998. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
- ↑ 3.0 3.1 "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11027.
- ↑ "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology 1 (6): 16054. Apr 2016. doi:10.1038/NMICROBIOL.2016.54. PMID 27572839.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells.". J. Immunol. 158 (1): 9–12. 1997. doi:10.4049/jimmunol.158.1.9. PMID 8977169.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. 2003. doi:10.1073/pnas.0337567100. PMID 12529506. Bibcode: 2003PNAS..100.1174T.
- "Transcriptional regulation of ILT family receptors.". J. Immunol. 171 (12): 6611–20. 2004. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
- "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.". Blood 104 (9): 2832–9. 2004. doi:10.1182/blood-2004-01-0268. PMID 15242876.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- LILRA2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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