Biology:LILRA3
 Generic protein structure example |
Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,[1] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.[2][3][4]
Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [5]
See also
References
- ↑ "Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion". European Journal of Immunology 30 (12): 3655–62. December 2000. doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y. PMID 11169408.
- ↑ "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology 159 (5): 2342–9. September 1997. doi:10.4049/jimmunol.159.5.2342. PMID 9278324.
- ↑ "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology 159 (11): 5192–6. December 1997. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
- ↑ "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11026.
- ↑ "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". Journal of Immunology 186 (5): 2990–7. March 2011. doi:10.4049/jimmunol.1003078. PMID 21270408.
Further reading
- "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology 27 (3): 660–5. March 1997. doi:10.1002/eji.1830270313. PMID 9079806.
- "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine 185 (10): 1743–51. May 1997. doi:10.1084/jem.185.10.1743. PMID 9151699.
- "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine 186 (11): 1809–18. December 1997. doi:10.1084/jem.186.11.1809. PMID 9382880.
- "Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls". Human Immunology 64 (4): 458–61. April 2003. doi:10.1016/S0198-8859(03)00025-9. PMID 12651072.
- "DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3". Immunogenetics 55 (3): 165–71. June 2003. doi:10.1007/s00251-003-0561-1. PMID 12750859.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science 13 (10): 2819–24. October 2004. doi:10.1110/ps.04682504. PMID 15340161.
External links
- LILRA3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q8N6C8 (Leukocyte immunoglobulin-like receptor subfamily A member 3) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
