Biology:SOCS6
From HandWiki
 Generic protein structure example |
Suppressor of cytokine signaling 6 is a protein that in humans is encoded by the SOCS6 gene.[1][2][3]
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI) protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.[3]
References
- ↑ "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun 239 (2): 439–46. Nov 1997. doi:10.1006/bbrc.1997.7484. PMID 9344848.
- ↑ "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. Nov 2000. doi:10.1101/gr.140200. PMID 11042152.
- ↑ 3.0 3.1 "Entrez Gene: SOCS6 suppressor of cytokine signaling 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9306.
Further reading
- "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. 2002. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem. 276 (28): 25889–93. 2001. doi:10.1074/jbc.M010579200. PMID 11342531.
- "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. 2002. doi:10.1128/MCB.22.13.4567-4578.2002. PMID 12052866.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem. 279 (13): 12249–59. 2004. doi:10.1074/jbc.M313381200. PMID 14707129.
- "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.". FEBS Lett. 580 (11): 2609–14. 2006. doi:10.1016/j.febslet.2006.03.093. PMID 16643902.
- "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.". Biochem. Biophys. Res. Commun. 354 (1): 184–9. 2007. doi:10.1016/j.bbrc.2006.12.175. PMID 17210122.
- "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels.". Biochem. Biophys. Res. Commun. 360 (2): 333–8. 2007. doi:10.1016/j.bbrc.2007.06.062. PMID 17603019.
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