Biology:11-cis-retinol dehydrogenase

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Short description: Class of enzymes
11-cis-retinol dehydrogenase
Identifiers
EC number1.1.1.315
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

11-cis-retinol dehydrogenase (EC 1.1.1.315, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

11-cis-retinol---[retinal-binding-protein] + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 11-cis-retinal---[retinol-binding-protein] + NADH + H+

This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.

References

  1. "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". The Journal of Biological Chemistry 270 (3): 1107–12. January 1995. doi:10.1074/jbc.270.3.1107. PMID 7836368. 
  2. "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". The Biochemical Journal 338 ( Pt 1): 23–7. February 1999. doi:10.1042/0264-6021:3380023. PMID 9931293. 
  3. "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". The Journal of Biological Chemistry 276 (52): 49251–7. December 2001. doi:10.1074/jbc.M107337200. PMID 11675386. 
  4. "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". The Journal of Biological Chemistry 278 (14): 12390–6. April 2003. doi:10.1074/jbc.M212775200. PMID 12536149. 

External links