Biology:Enoyl-acyl carrier protein reductase
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Short description: InterPro Family
| Enoyl-acyl carrier protein reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Enoyl-[acyl-carrier-protein] reductase [NADH] tetramer, Mycobacterium tuberculosis | |||||||||
| Identifiers | |||||||||
| EC number | 1.3.1.9 | ||||||||
| CAS number | 37251-08-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Enoyl-acyl carrier protein reductase (or ENR) (EC 1.3.1.9), is a key enzyme of the type II fatty acid synthesis (FAS) system.[1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.[2]
At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.[3]
See also
- Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
- Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
- Cis-2-enoyl-CoA reductase (NADPH)
References
- ↑ "Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum". The Biochemical Journal 381 (Pt 3): 735–41. August 2004. doi:10.1042/BJ20040302. PMID 15139852.
- ↑ "Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase". Antimicrobial Agents and Chemotherapy 48 (5): 1541–7. May 2004. doi:10.1128/aac.48.5.1541-1547.2004. PMID 15105103.
- ↑ "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae". The Journal of Antibiotics 59 (12): 808–12. December 2006. doi:10.1038/ja.2006.108. PMID 17323650.
External links
- NADH-Enoyl+ACP+Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 1.3.1.9
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