Biology:Phosphonoacetaldehyde reductase (NADH)
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Phosphonoacetaldehyde reductase (NADH) | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.309 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- 2-hydroxyethylphosphonate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] phosphonoacetaldehyde + NADH + H+
The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.
References
- ↑ "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide". Nature Chemical Biology 3 (8): 480–5. August 2007. doi:10.1038/nchembio.2007.9. PMID 17632514.
External links
- Phosphonoacetaldehyde+reductase+(NADH) at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Phosphonoacetaldehyde reductase (NADH).
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