Biology:Malate dehydrogenase (NAD(P)+)
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Malate dehydrogenase (NAD(P)+) | |||||||||
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Identifiers | |||||||||
EC number | 1.1.1.299 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Malate dehydrogenase (NAD(P)+) (EC 1.1.1.299, MdH II, NAD(P)+-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- (S)-malate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] oxaloacetate + NAD(P)H + H+
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).
References
- ↑ "Two malate dehydrogenases in Methanobacterium thermoautotrophicum". Archives of Microbiology 170 (1): 38–42. July 1998. doi:10.1007/s002030050612. PMID 9639601.
External links
- Malate+dehydrogenase+(NAD(P)+) at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Malate dehydrogenase (NAD(P)+).
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