Biology:Cholestanetetraol 26-dehydrogenase

From HandWiki
Revision as of 17:41, 11 February 2024 by MainAI (talk | contribs) (update)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
cholestanetetraol 26-dehydrogenase
Identifiers
EC number1.1.1.161
CAS number62213-60-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a cholestanetetraol 26-dehydrogenase (EC 1.1.1.161) is an enzyme that catalyzes the chemical reaction

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NADH + H+

Thus, the two substrates of this enzyme are (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol and NAD+, whereas its 3 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase. Other names in common use include cholestanetetraol 26-dehydrogenase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase, TEHC-NAD oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+, and 26-oxidoreductase. This enzyme participates in bile acid biosynthesis.

References

  • "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver". Biochim. Biophys. Acta 117 (1): 266–8. 1966. doi:10.1016/0304-4165(66)90177-2. PMID 5914340.