Biology:8-oxo-dGDP phosphatase
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Short description: Class of enzymes
| 8-oxo-dGDP phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.1.58 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
8-oxo-dGDP phosphatase (EC 3.6.1.58, NUDT5) is an enzyme with systematic name 8-oxo-dGDP phosphohydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- 8-oxo-dGDP + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 8-oxo-dGMP + phosphate
The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP.
References
- ↑ "Mammalian enzymes for preventing transcriptional errors caused by oxidative damage". Nucleic Acids Research 33 (12): 3779–84. 2005. doi:10.1093/nar/gki682. PMID 16002790.
- ↑ "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Reports 4 (5): 479–83. May 2003. doi:10.1038/sj.embor.embor838. PMID 12717453.
- ↑ "NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity". DNA Repair 8 (10): 1250–4. October 2009. doi:10.1016/j.dnarep.2009.07.011. PMID 19699693.
- ↑ "Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein". Journal of Biochemistry 149 (6): 731–8. June 2011. doi:10.1093/jb/mvr028. PMID 21389046.
- ↑ "Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity". Journal of Molecular Biology 364 (5): 1021–33. December 2006. doi:10.1016/j.jmb.2006.09.078. PMID 17052728.
External links
- 8-oxo-dGDP+phosphatase at the US National Library of Medicine Medical Subject Headings (MeSH)
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