Biology:Flavonol synthase
| flavonol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.23 | ||||||||
| CAS number | 146359-76-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a flavonol synthase (EC 1.14.11.23) is an enzyme that catalyzes the following chemical reaction :
dihydroflavonol + 2-oxoglutarate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] a flavonol + succinate + CO2 + H2O
The 3 substrates of this enzyme are dihydroflavonol, 2-oxoglutarate, and O2, whereas its 4 products are flavonol, succinate, CO2, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor. The systematic name of this enzyme class is dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase. This enzyme participates in flavonoid biosynthesis.
References
- "Functional expression and mutational analysis of flavonol synthase from Citrus unshiu". Eur. J. Biochem. 269 (16): 4134–42. 2002. doi:10.1046/j.1432-1033.2002.03108.x. PMID 12180990.
- "Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase". Phytochemistry 62 (3): 287–92. 2003. doi:10.1016/S0031-9422(02)00567-8. PMID 12620339.
- "Divergent evolution of flavonoid 2-oxoglutarate-dependent dioxygenases in parsley". FEBS Lett. 544 (1-3): 93–8. 2003. doi:10.1016/S0014-5793(03)00479-4. PMID 12782296.
- CJ; Nakajima, J; Welford, RW; Yamazaki, M; Saito, K; Schofield, CJ (2004). "Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase". J. Biol. Chem. 279 (2): 1206–16. doi:10.1074/jbc.M309228200. PMID 14570878.
 |  |
