Biology:Secoisolariciresinol dehydrogenase
From HandWiki
| Secoisolariciresinol dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.331 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with the systematic name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction:
- (-)-secoisolariciresinol + 2 NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] (-)-matairesinol + 2 NADH + 2 H+
This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.
References
- ↑ "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". The Journal of Biological Chemistry 276 (16): 12614–23. April 2001. doi:10.1074/jbc.M008622200. PMID 11278426.
- ↑ "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". The Journal of Biological Chemistry 280 (13): 12917–26. April 2005. doi:10.1074/jbc.M413266200. PMID 15653677.
- ↑ "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Organic & Biomolecular Chemistry 4 (5): 808–16. March 2006. doi:10.1039/b516563f. PMID 16493463.
External links
- Secoisolariciresinol+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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