Biology:Acetyl-CoA C-acetyltransferase
| acetyl-CoA C-acetyltransferase | |||||||||
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 Crystallographic structure of the tetrameric acetoacetyl-CoA thiolase (EC:2.3.1.9) from the Gram-negative bacterium Z. ramigera.[1] | |||||||||
| Identifiers | |||||||||
| EC number | 2.3.1.9 | ||||||||
| CAS number | 9027-46-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction
- 2 acetyl-CoA [math]\displaystyle{ \rightleftharpoons }[/math] CoA + acetoacetyl-CoA
Hence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA.
Acetyl-CoA C-acetyltransferase belongs to the thiolase family of enzymes.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in 10 metabolic pathways: fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, benzoate degradation via coa ligation, propanoate metabolism, butanoate metabolism, and two-component system - general.
Isozymes
Human genes encoding acetyl-CoA C-acetyltransferases include:
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References
Further reading
- "Enzymes of fatty acid metabolism". Biochim. Biophys. Acta 12 (1–2): 299–314. 1953. doi:10.1016/0006-3002(53)90149-8. PMID 13115439.
- "Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver". J. Biol. Chem. 235 (2): 313–317. 1960. doi:10.1016/S0021-9258(18)69521-3. PMID 13834445.
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