Biology:2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
| 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.127 | ||||||||
| CAS number | 37250-56-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (EC 1.1.1.127) is an enzyme that catalyzes the chemical reaction
- 2-dehydro-3-deoxy-D-gluconate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] (4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+
Thus, the two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconate and NAD+, whereas its 3 products are (4S)-4,6-dihydroxy-2,5-dioxohexanoate, NADH, and H+.
This enzyme participates in pentose and glucuronate interconversions.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase. Other names in common use include 2-keto-3-deoxygluconate 5-dehydrogenase, 2-keto-3-deoxy-D-gluconate dehydrogenase, 2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide, (phosphate)) dehydrogenase, 2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic, and acid) dehydrogenase.
References
- Condemine G; Hugouvieux-Cotte-Pattat N; Robert-Baudouy J (1984). "An enzyme in the pectolytic pathway of Erwinia chrysanthemi: 3-keto-3-deoxygluconate oxidoreductase". J. Gen. Microbiol. 130: 2839–2844. doi:10.1099/00221287-130-11-2839.
- "Polygalacturonic acid metabolism in bacteria. II. Formation and metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid". The Journal of Biological Chemistry 238: 1577–83. May 1963. PMID 13986017.
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