Biology:Glucuronate reductase
| L-glucuronate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.19 | ||||||||
| CAS number | 9028-29-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glucuronate reductase (EC 1.1.1.19) is an enzyme that catalyzes the chemical reaction
- L-gulonate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] D-glucuronate + NADPH + H+
Thus, the two substrates of this enzyme are L-gulonate and NADP+, whereas its 3 products are D-glucuronate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-gulonate:NADP+ 6-oxidoreductase. Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
- "Enzymes of mesoinositol catabolism in the yeast Schwanniomyces occidentalis". Biochim. Biophys. Acta 53 (2): 426–8. 1961. doi:10.1016/0006-3002(61)90462-0. PMID 13913518.
- Jakoby, W. B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249–260.
- "TPN-L-gluonate dehydrogenase". Biochim. Biophys. Acta 47 (2): 298–306. 1961. doi:10.1016/0006-3002(61)90290-6. PMID 13787380.
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