Biology:1,8-Cineole 2-exo-monooxygenase
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Short description: Class of enzymes
| 1,8-Cineole 2-exo-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.157 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157, CYP3A4) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction
- 1,8-cineole + NADPH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 2-exo-hydroxy-1,8-cineole + NADP+ + H2O
1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).
References
- ↑ "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metabolism and Disposition 29 (2): 200–5. February 2001. PMID 11159812.
- ↑ "Biotransformation of 1,8-cineole by human liver microsomes". Natural Product Letters 15 (1): 49–53. 2001. doi:10.1080/10575630108041257. PMID 11547423.
- ↑ "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica; The Fate of Foreign Compounds in Biological Systems 31 (10): 713–23. October 2001. doi:10.1080/00498250110065595. PMID 11695850.
External links
- 1,8-cineole+2-exo-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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