Biology:EGLN2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.[1] ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.
The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[1]
References
Further reading
- Semenza GL (2001). "HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus". Cell 107 (1): 1–3. doi:10.1016/S0092-8674(01)00518-9. PMID 11595178.
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation". Science 292 (5516): 468–72. 2001. doi:10.1126/science.1059796. PMID 11292861. Bibcode: 2001Sci...292..468J.
- "HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing". Science 292 (5516): 464–8. 2001. doi:10.1126/science.1059817. PMID 11292862. Bibcode: 2001Sci...292..464I.
- Taylor MS (2001). "Characterization and comparative analysis of the EGLN gene family". Gene 275 (1): 125–32. doi:10.1016/S0378-1119(01)00633-3. PMID 11574160.
- "C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation". Cell 107 (1): 43–54. 2001. doi:10.1016/S0092-8674(01)00507-4. PMID 11595184.
- "A conserved family of prolyl-4-hydroxylases that modify HIF". Science 294 (5545): 1337–40. 2001. doi:10.1126/science.1066373. PMID 11598268. Bibcode: 2001Sci...294.1337B.
- "Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)". Oncogene 21 (5): 836–43. 2002. doi:10.1038/sj.onc.1205113. PMID 11850811.
- "Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling". Science 296 (5574): 1886–9. 2002. doi:10.1126/science.1073440. PMID 12004076. Bibcode: 2002Sci...296.1886M.
- "The use of dioxygen by HIF prolyl hydroxylase (PHD1)". Bioorg. Med. Chem. Lett. 12 (12): 1547–50. 2002. doi:10.1016/S0960-894X(02)00219-6. PMID 12039559.
- "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9. 2002. doi:10.1016/S0006-291X(02)00862-8. PMID 12163023.
- "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13459–64. 2002. doi:10.1073/pnas.192342099. PMID 12351678. Bibcode: 2002PNAS...9913459I.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing". J. Cell Sci. 116 (Pt 7): 1319–26. 2003. doi:10.1242/jcs.00318. PMID 12615973.
- "Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells". Biochem. Biophys. Res. Commun. 303 (3): 947–53. 2003. doi:10.1016/S0006-291X(03)00453-4. PMID 12670503.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors". J. Cell. Biochem. 92 (3): 491–501. 2004. doi:10.1002/jcb.20067. PMID 15156561. https://zenodo.org/record/1229216.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
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