Biology:Protein-glutamine gamma-glutamyltransferase

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protein-glutamine gamma-glutamyltransferase
Identifiers
EC number2.3.2.13
CAS number80146-85-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a protein-glutamine gamma-glutamyltransferase (EC 2.3.2.13) is an enzyme that catalyzes the chemical reaction

protein glutamine + alkylamine [math]\displaystyle{ \rightleftharpoons }[/math] protein N5-alkylglutamine + NH3

Thus, the two substrates of this enzyme are protein glutamine and alkylamine, whereas its two products are protein N(5)-alkylglutamine and NH3.

This enzyme participates in complement and coagulation cascades and Huntington's disease. It employs one cofactor, calcium.

Nomenclature

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is protein-glutamine:amine gamma-glutamyltransferase. Other names in common use include:

  • factor XIIIa,
  • fibrin stabilizing factor,
  • fibrinoligase,
  • glutaminylpeptide gamma-glutamyltransferase,
  • polyamine transglutaminase,
  • R-glutaminyl-peptide:amine gamma-glutamyl transferase
  • tissue transglutaminase, and
  • transglutaminase.


Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1EVU, 1EX0, 1F13, 1FIE, 1G0D, 1GGT, 1GGU, 1GGY, 1IU4, 1KV3, 1L9M, 1L9N, 1NUD, 1NUF, 1NUG, 1QRK, 1RLE, 1SGX, and 1VJJ.

References

* "Molecular and catalytic properties of transglutaminases". Adv. Enzymol. Relat. Areas Mol. Biol.. Advances in Enzymology - and Related Areas of Molecular Biology 38: 109–91. 1973. doi:10.1002/9780470122839.ch3. ISBN 978-0-470-12283-9. PMID 4151471.