Biology:2,5-diketocamphane 1,2-monooxygenase
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Short description: Class of enzymes
| 2,5-diketocamphane 1,2-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.14.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2,5-diketocamphane 1,2-monooxygenase (EC 1.14.14.108, 2,5-diketocamphane lactonizing enzyme, ketolactonase I, 2,5-diketocamphane 1,2-monooxygenase oxygenating component, 2,5-DKCMO, camphor 1,2-monooxygenase, camphor ketolactonase I) is an enzyme with systematic name (+)-bornane-2,5-dione,NADH:oxygen oxidoreductase (1,2-lactonizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (+)-bornane-2,5-dione + O2 + NADH + H+ [math]\displaystyle{ \rightleftharpoons }[/math] (+)-5-oxo-1,2-campholide + NAD+ + H2O
2,5-diketocamphane 1,2-monooxygenase is a flavoprotein (FMN) which requires Fe2+.
References
- ↑ "Mixed function oxidation. II. Separation and properties of the enzymes catalyzing camphor lactonizaton". The Journal of Biological Chemistry 240: 495–503. January 1965. doi:10.1016/S0021-9258(18)97679-9. PMID 14253460.
- ↑ "Monoxygenases. VII. Camphor ketolactonase I and the role of three protein components". The Journal of Biological Chemistry 244 (22): 6149–52. November 1969. doi:10.1016/S0021-9258(18)63518-5. PMID 4310834.
- ↑ "Camphor revisited: studies of 2,5-diketocamphane 1,2-monooxygenase from Pseudomonas putida ATCC 17453". Journal of Bacteriology 165 (2): 489–97. February 1986. doi:10.1128/jb.165.2.489-497.1986. PMID 3944058.
- ↑ "Microbial oxidation of adamantanone by Pseudomonas putida carrying the camphor catabolic plasmid". Biochemical and Biophysical Research Communications 186 (3): 1429–36. August 1992. doi:10.1016/s0006-291x(05)81566-9. PMID 1510672.
- ↑ "Diketocamphane enantiomer-specific 'Baeyer-Villiger' monooxygenases from camphor-grown Pseudomonas putida ATCC 17453". Journal of General Microbiology 139 (4): 797–805. April 1993. doi:10.1099/00221287-139-4-797. PMID 8515237.
- ↑ "Recombinant expression and purification of the 2,5-diketocamphane 1,2-monooxygenase from the camphor metabolizing Pseudomonas putida strain NCIMB 10007". AMB Express 1 (1): 13. June 2011. doi:10.1186/2191-0855-1-13. PMID 21906366.
External links
- 2,5-diketocamphane+1,2-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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