Biology:Inorganic diphosphatase
From HandWiki
| inorganic diphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Pyrophosphatase (inorganic) hexamer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC number | 3.6.1.1 | ||||||||
| CAS number | 9024-82-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an inorganic diphosphatase (EC 3.6.1.1) is an enzyme that catalyzes the chemical reaction
- diphosphate + H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2 phosphate
Thus, the two substrates of this enzyme are diphosphate and H2O, whereas its product is phosphate.[1]
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is diphosphate phosphohydrolase. This enzyme participates in oxidative phosphorylation. It employs one cofactor, metal.
References
- ↑ Rafter GW (1960). "Pyrophosphate metabolism in liver mitochondria". J. Biol. Chem. 235: 2475–2477.
Further reading
- Bailey K; Webb EC (1944). "Purification and properties of yeast pyrophosphatase". Biochem. J. 38 (5): 394–398. PMID 16747821.
- KUNITZ M (1952). "CRYSTALLINE INORGANIC PYROPHOSPHATASE ISOLATED FROM BAKER'S YEAST". J. Gen. Physiol. 35 (3): 423–50. doi:10.1085/jgp.35.3.423. PMID 14898026.
- "Molecular cloning and sequence of cDNA encoding the pyrophosphate-energized vacuolar membrane proton pump of Arabidopsis thaliana". Proc. Natl. Acad. Sci. U.S.A. 89 (5): 1775–9. March 1992. doi:10.1073/pnas.89.5.1775. PMID 1311852.
- "A thermostable vacuolar-type membrane pyrophosphatase from the archaeon Pyrobaculum aerophilum: implications for the origins of pyrophosphate-energized pumps". FEBS Lett. 460 (3): 505–12. November 1999. doi:10.1016/S0014-5793(99)01404-0. PMID 10556526.
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