Biology:(S)-2-hydroxypropylphosphonic acid epoxidase
From HandWiki
Short description: Class of enzymes
| (S)-2-hydroxypropylphosphonic acid epoxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.19.7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
(S)-2-hydroxypropylphosphonic acid epoxidase (EC 1.14.19.7, HPP epoxidase, HppE, 2-hydroxypropylphosphonic acid epoxidase, Fom4, (S)-2-hydroxypropylphosphonate epoxidase) is an enzyme with systematic name (S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- (S)-2-hydroxypropylphosphonate + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (1R,2S)-epoxypropylphosphonate + NAD+ + 2 H2O
(S)-2-hydroxypropylphosphonic acid epoxidase contains one non-heme iron centre per monomer.
References
- ↑ "Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae". Biochemistry 47 (33): 8726–35. August 2008. doi:10.1021/bi800877v. PMID 18656958.
- ↑ "Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues". Biochemistry 46 (44): 12628–38. November 2007. doi:10.1021/bi701370e. PMID 17927218.
- ↑ "Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis". Molecular & General Genetics 249 (3): 274–80. November 1995. doi:10.1007/bf00290527. PMID 7500951.
- ↑ "Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis". Journal of the American Chemical Society 126 (33): 10306–12. August 2004. doi:10.1021/ja0475050. PMID 15315444.
- ↑ "Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme". Nature 437 (7060): 838–44. October 2005. doi:10.1038/nature03924. PMID 16015285.
- ↑ "Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis". Acta Crystallographica Section F 61 (Pt 5): 534–6. May 2005. doi:10.1107/S1744309105012376. PMID 16511089.
External links
- (S)-2-hydroxypropylphosphonic+acid+epoxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
