Biology:1-alkenylglycerophosphoethanolamine O-acyltransferase
In enzymology, a 1-alkenylglycerophosphoethanolamine O-acyltransferase (EC 2.3.1.121) is an enzyme that catalyzes the chemical reaction: acyl-CoA + 1-alkenylglycerophosphoethanolamine CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
| 1-alkenylglycerophosphoethanolamine O-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.121 | ||||||||
| CAS number | 112445-17-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are acyl-CoA and 1-alkenylglycerophosphoethanolamine, whereas its two products are CoA and 1-alkenyl-2-acylglycerophosphoethanolamine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase. This enzyme participates in ether lipid metabolism.
1-alkenylglycerophosphoethanolamine O-acyltransferase creates certain plasmalogens that carry beneficial effects, such as increasing brain health, cardiovascular function, and preventing chronic inflammation.[1][2]
They also have a strong substrate preference for long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA). This means that they specifically select omega-3 and omega-6 chains to complete the lipid, which directly enriches the membranes of the brain and retina, since they are essential for visual acuity and cognitive processing.[3][4] When this enzyme is functioning well, it also allows cells to remove excess cholesterol, helping protect arterial walls and prevent atherosclerosis.[5]
References
- ↑ Curran, Colleen S.; Remaley, Alan T.; Torabi-Parizi, Parizad (2025-12-01). "Plasmalogens as biomarkers and therapeutic targets" (in English). Journal of Lipid Research 66 (12). doi:10.1016/j.jlr.2025.100925. ISSN 0022-2275. PMID 41130295. https://www.jlr.org/article/S0022-2275(25)00188-9/abstract.
- ↑ "Plasmalogens | Integrative Medicine" (in en-US). https://www.cirm1.org/plasmalogens/.
- ↑ "EC 2.3.1.121". https://iubmb.qmul.ac.uk/enzyme/EC2/3/1/121.html.
- ↑ Wang, Tingting; Huynh, Kevin; Giles, Corey; Mellett, Natalie A; Duong, Thy; Nguyen, Anh; Lim, Wei Ling Florence; Smith, Alex AT et al. (2022). "APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies" (in en). Alzheimer's & Dementia 18 (11): 2151–2166. doi:10.1002/alz.12538. ISSN 1552-5279. PMID 35077012. PMC 9787288. https://onlinelibrary.wiley.com/doi/abs/10.1002/alz.12538.
- ↑ Paul, Sudip; Smith, Adam Alexander T.; Culham, Kevin; Gunawan, Kevin A.; Weir, Jacqueline M.; Cinel, Michelle A.; Jayawardana, Kaushala S.; Mellett, Natalie A. et al. (2021). "Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation". Journal of Lipid Research 62. doi:10.1016/j.jlr.2021.100092. ISSN 1539-7262. PMID 34146594. PMC 8281607. https://pmc.ncbi.nlm.nih.gov/articles/PMC8281607/.
- "Acylation of 1-alkenylglycerophosphoethanolamine and 1-acylglycerophosphoethanolamine in guinea-pig heart microsomes". Biochim. Biophys. Acta 921 (2): 259–65. 1987. doi:10.1016/0005-2760(87)90026-9. PMID 3651487.
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