Biology:12beta-hydroxysteroid dehydrogenase
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Short description: Class of enzymes
| 12-beta-hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.238 | ||||||||
| CAS number | 118390-62-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 12beta-hydroxysteroid dehydrogenase (EC 1.1.1.238) is an enzyme that catalyzes the chemical reaction
- 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+
Thus, the two substrates of this enzyme are 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate and NADP+, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12beta-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), and dehydrogenase.
References
- "Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum". Biochim. Biophys. Acta 962 (3): 362–70. 1988. doi:10.1016/0005-2760(88)90266-4. PMID 3167086.
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