Biology:2-deoxy-D-gluconate 3-dehydrogenase
From HandWiki
Short description: Class of enzymes
| 2-deoxy-D-gluconate 3-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.125 | ||||||||
| CAS number | 37250-54-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125) is an enzyme that catalyzes the chemical reaction
- 2-deoxy-D-gluconate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 3-dehydro-2-deoxy-D-gluconate + NADH + H+
Thus, the two substrates of this enzyme are 2-deoxy-D-gluconate and NAD+, whereas its 3 products are 3-dehydro-2-deoxy-D-gluconate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-deoxy-D-gluconate:NAD+ 3-oxidoreductase. This enzyme is also called 2-deoxygluconate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1X1E.
References
- "Microbial metabolism of 2-deoxyglucose; 2-deoxyglucose acid dehydrogenase". Biochemistry 4: 159–65. January 1965. doi:10.1021/bi00877a024. PMID 14285233.
 |  |
