Biology:2-hydroxyquinoline 5,6-dioxygenase

From HandWiki
Short description: Class of enzymes
2-hydroxyquinoline 5,6-dioxygenase
Identifiers
EC number1.14.12.16
CAS number172399-50-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 2-hydroxyquinoline 5,6-dioxygenase (EC 1.14.12.16) is an enzyme that catalyzes the chemical reaction

quinolin-2-ol + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+

The 4 substrates of this enzyme are quinolin-2-ol, NADH, H+, and O2, whereas its two products are 2,5,6-trihydroxy-5,6-dihydroquinoline and NAD+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating). Other names in common use include 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase, quinolin-2-ol 5,6-dioxygenase, and quinolin-2(1H)-one 5,6-dioxygenase.

References

  • "Quinoline 2-oxidoreductase and 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase from Comamonas testosteroni 63. The first two enzymes in quinoline and 3-methylquinoline degradation". Eur. J. Biochem. 232 (2): 536–44. 1995. doi:10.1111/j.1432-1033.1995.tb20841.x. PMID 7556204.